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Upcoming Talks:

IPNV VP1 We are interested in the molecular mechanisms used by viruses to invade host cells, establish an infection and ensure that progeny virus particles are released into the environment, all while evading the host's immune defences. We are especially interested in how large double-stranded DNA viruses like herpes simplex virus and vaccinia virus (the smallpox vaccine) subvert the membrane trafficking machinery and innate immune defences of human cells.

To study these problems we use a host of structural, biochemical, biophysical and cell-based techniques including protein X-ray crystallography, mass spectrometry, fluorescence microscopy, infection studies, multi-angle light scattering, differential scanning fluorimetry, isothermal titration calorimetry, surface plasmon resonance and fluorescence anisotropy.

UL51 UL7 IF By using viruses as tools to better understand the inner workings of cells, we aim to make insights into virus biology that will underpin the next generation of vaccines and anti-viral drugs.

Most importantly, we work as a team to do great science. Ours is a collaborative lab environment that aims to support the personal and professional development of every member, regardless of their background, gender identity, colour, accent or who they love.

Lab in April 2024