Diamond How does the herpes virus hijack our cells? Cryo-SXT can show us...
Diamond Light Source / PLoS Pathogens
EMBL Flexibility is key for herpesvirus hijacking of cellular machinery
EMBL / PLoS Pathogens
Cell Reports 2020 Proteomics of HSV infection
Cell Reports
eLife digest How herpes viruses put on their protective coat
eLife digest
Nat Comms April 2018 The mechanism of sphingolipid processing revealed by a GALC-SapA complex structure
Nature Communications
Traffic January 2017 Cellular and viral peptides bind multiple sites on the N-terminal domain of clathrin
Traffic
Structure 13 July 2011 into the evolution of a complex virus from the crystal structure of vaccinia virus D13
Structure

Online Preprints

*Joint first authors, ^Joint senior authors
  1. C. Lefévre, G.M. Cook, A.M. Dinan, S. Torii, H. Stewart, G. Gibbons, A.S. Nicholson, L. Echavarria-Consuegra, L.W. Meredith, V. Lulla, J.C. Kenyon, I.G. Goodfellow, J.E. Deane, S.C. Graham, A. Lakatos, L. Lambrechts, I. Brierley, N. Irigoyen (2023) Zika viruses encode multiple upstream open reading frames in the 5' viral region with a role in neurotropism. BioRχiv online preprint doi: 10.1101/112904

Publications

*Joint first authors, ^Joint senior authors
  1. H. Ali, A. Lulla, A.S. Nicholson, J. Hankinson, E.B. Wignall-Fleming, R.L. O'Connor, D.L. Vu, S.C. Graham, J.E. Deane, S. Guix, V. Lulla (2023) Attenuation hotspots in neurotropic human astroviruses. PLoS Biology, in press doi: 10.1371/journal.pbio.3001815
  2. S.J. McKie, A.S. Nicholson, E. Smith, S. Fawke, E. Caroe, J.C. Williamson, B.G. Butt, D. Kolarov, O. Peterka, M. Holcapek, P.J. Lehner, S.C. Graham, J.E. Deane (2023) Altered plasma membrane abundance of the sulfatide-binding protein NF155 links glycosphingolipid imbalances to demyelination. Proceedings of the National Academy of Sciences of the USA, 120: e2218823120 doi: 10.1073/pnas.2218823120
  3. N.S. Barbosa, J.O. Concha, L.L.P. da Silva, C.M. Crump^, S.C. Graham^ (2023) Oropouche virus glycoprotein topology and cellular requirements for glycoprotein secretion. Journal of Virology, 97: e01331-22 doi: 10.1128/jvi.01331-22 Author accepted manuscript available via the University of Cambridge Apollo repository, doi: 10.17863/CAM.90939
  4. I.M. Hay, M. Shamin, E.R. Caroe, A.S.A. Mohammed, D.I. Svergun, C.M Jeffries, S.C. Graham, H.J. Sharpe^, J.E. Deane^ (2023) Determinants of receptor tyrosine phosphatase homophilic adhesion: Structural comparison of PTPRK and PTPRM extracellular domains. Journal of Biological Chemistry, 299: 102750 doi: 10.1016/j.jbc.2022.102750
  5. T.H. Benedyk, V. Connor, E.R. Caroe, M. Shamin, D.I. Svergun, J.E. Deane, C.M. Jeffries, C.M. Crump, S.C. Graham (2022) Herpes simplex virus 1 protein pUL21 alters ceramide metabolism by activating the inter-organelle transport protein CERT. Journal of Biological Chemistry, 298: 102589 doi: 10.1016/j.jbc.2022.102589
  6. I.M. Hay, K.E. Mulholland, T. Lai, S.C. Graham, H.J. Sharpe^, J.E. Deane^ (2022) Molecular mechanism of Afadin substrate recruitment to the receptor phosphatase PTPRK via its pseudophosphatase domain. eLife, 11: e79855 doi: 10.7554/eLife.79855
  7. K.L. Nahas, V. Connor, K.M. Scherer, C.F. Kaminski, M. Harkiolaki^, C.M. Crump^, S.C. Graham^ (2022) Near-native state imaging by cryo-soft-X-ray tomography reveals remodelling of multiple cellular organelles during HSV-1 infection. PLoS Pathogens, 18: e1010629 doi: 10.1371/journal.ppat.1010629
  8. K.L. Nahas^, J.F. Fernandes, N. Vyas, C.M. Crump, S.C. Graham, M. Harkiolaki^ (2022) Contour: a semi-automated segmentation and quantitation tool for cryo-soft-X-ray tomography. Biological Imaging, 2: e3 doi: 10.1101/2021.12.03.470962
  9. W.N.D. Gao, C. Gao, J.E. Deane, D.C.J. Carpentier, G.L. Smith, S.C. Graham (2022) The crystal structure of vaccinia virus protein E2 and perspectives on the prediction of novel viral protein folds. Journal of General Virology, 103: 001716 doi: 10.1099/jgv.0.001716
  10. C.H Hill*^, L. Pekarek*, S. Napthine*, A. Kibe, A.E. Firth, S.C. Graham^, N. Caliskan^, I. Brierley^ (2021) Structural and molecular basis for Cardiovirus 2A protein as a viral gene expression switch. Nature Communications, 12: 7166 doi: 10.1038/s41467-021-27400-7
  11. M. Shamin, S.J. Spratley, S.C. Graham, J.E. Deane (2021) A tetrameric assembly of saposin A: increasing structural diversity in lipid transfer proteins. Contact, 4: 1–11 doi: 10.1177/25152564211052382
  12. C.H Hill*^, G.M. Cook*, S. Napthine*, A. Kibe, K. Brown, N. Caliskan, A.E. Firth^, S.C. Graham^, I. Brierley^ (2021) Investigating molecular mechanisms of 2A-stimulated ribosomal pausing and frameshifting in Theilovirus. Nucleic Acids Research, 49: 11938–11958 doi: 10.1093/nar/gkab969
  13. T.H. Benedyk, J. Muenzner, V. Connor, Y. Han, K. Brown, K.J. Wijesinghe, Y. Zhuang, S. Colaco, G.A. Stoll, O.S. Tutt, S. Svobodova, D.I. Svergun, N.A. Bryant, J.E. Deane, A.E. Firth, C.M. Jeffries, C.M. Crump^, S.C. Graham^ (2021) pUL21 is a viral phosphatase adaptor that promotes herpes simplex virus replication and spread. PLoS Pathogens, 17: e1009824 doi: 10.1371/journal.ppat.1009824
  14. G. Gallo, C. Conceicao, C. Tsirigoti, B. Willett, S.C. Graham, D. Bailey (2021) Application of error-prone PCR to functionally probe the morbillivirus Haemagglutinin protein. Journal of General Virology, 102: 001580 doi: 10.1099/jgv.0.001580
  15. C. Conceicao*, N. Thakur*, S. Human, J.T. Kelly, L. Logan, D. Bialy, S. Bhat, P. Stevenson-Leggett, A.K. Zagrajek, P. Hollinghurst, M. Varga, C. Tsirigoti, M. Tully, C. Chiu, K. Moffat, A.P. Silesian, J.A. Hammond, H.J. Maier, E. Bickerton, H. Shelton, I. Dietrich, S.C. Graham, D. Bailey (2020) The SARS-CoV-2 Spike protein has a broad tropism for mammalian ACE2 proteins. PLoS Biology, 18: e3001016 doi: 10.1371/journal.pbio.3001016
  16. T.K. Soh*, C.T.R. Davies*, J. Muenzner*, L.M. Hunter, H.G. Barrow, V. Connor, C.R. Bouton, C. Smith, E. Emmott, R. Antrobus, S.C. Graham^, M.P. Weekes^, C.M. Crump^ (2020) Temporal Proteomic Analysis of Herpes Simplex Virus 1 Infection Reveals Cell-Surface Remodeling via pUL56-Mediated GOPC Degradation. Cell Reports, 33: 108235 doi: 10.1016/j.celrep.2020.108235
  17. B.G. Butt, E.J. Scourfield, S.C. Graham (2020) Non-native fold of the putative VPS39 zinc finger domain. [version 2; peer review: 2 approved]. Wellcome Open Research, 5: 154 doi: 10.12688/wellcomeopenres.16078.2
  18. B.G. Butt, D.J. Owen, C.M. Jeffries, L. Ivanova, C.H. Hill, J.W. Houghton, M.F. Ahmed, R. Antrobus, D.I. Svergun, J.J. Welch, C.M. Crump, S.C. Graham (2020) Insights into herpesvirus assembly from the structure of the pUL7:pUL51 complex. eLife, 9: e53789 doi: 10.7554/eLife.53789
  19. M. Shamin, T.H. Benedyk, S.C. Graham, J.E. Deane (2019) The lipid transfer protein Saposin B does not directly bind CD1d for lipid antigen loading. [version 2; peer review: 3 approved] Wellcome Open Research, 4: 117 doi: 10.12688/wellcomeopenres.15368.2
  20. S.C. Graham, B. Nagar, G.G. Privé, J.E. Deane (2019) Molecular models should not be published without the corresponding atomic coordinates. Proceedings of the National Academy of Sciences of the USA, 116: 11099–11100 doi: 10.1073/pnas.1904409116
  21. C. Gao, M.A. Pallett, T.I. Croll, G.L. Smith, S.C. Graham (2019) Molecular basis of cullin-3 (Cul3) ubiquitin ligase subversion by vaccinia virus protein A55. Journal of Biological Chemistry, 294: 6416–6429 doi: 10.1074/jbc.RA118.006561
  22. J.M. Alves, M. Carneiro, J.Y. Cheng, A. Lemos de Matos, M.M. Rahman, L. Loog, P.F. Campos, N. Wales, A. Eriksson, A. Manica, T. Strive, S.C. Graham, S. Afonso, D.J. Bell, L. Belmont, J.P. Day, S.J. Fuller, S. Marchandeau, W.J. Palmer, G. Queney, A.K. Surridge, F.G. Vieira, G. McFadden, R. Nielsen, M.T.P. Gilbert, P.J. Esteves, N. Ferrand, F.M. Jiggins (2019) Parallel adaptation of rabbit populations to myxoma virus. Science, 363: 1319–1326 doi: 10.1126/science.aau7285
  23. N. Abdullah, J.T. Kelly, S.C. Graham, J. Birch, D. Gonçalves-Carneiro, T. Mitchell, R. N. Thompson, K.A. Lythgoe, N. Logan, M.J. Hosie, V.N. Bavro, B.J. Willett, M.P. Heaton, D. Bailey (2018) Structure-guided identification of a non-human morbillivirus with zoonotic potential. Journal of Virology, 23: e01248-18 doi: 10.1128/JVI.01248-18
  24. M.R. Hunter, G.G. Hesketh, T.H. Benedyk, A.C. Gingras, S.C. Graham (2018) Proteomic and biochemical comparison of the cellular interaction partners of human VPS33A and VPS33B. Journal of Molecular Biology, 430: 2153–2163 doi: 10.1016/j.jmb.2018.05.019
  25. R.C. Fleith*, H.V. Mears*, X.Y. Leong, T.J. Sanford, E. Emmott, S.C. Graham, D.S. Mansur, T.R. Sweeney (2018) IFIT3 and IFIT2/3 promote IFIT1-mediated translation inhibition by enhancing binding to non-self RNA. Nucleic Acids Research, 46: 5269–5285 doi: 10.1093/nar/gky191
  26. C.H. Hill, G.M. Cook, S.J. Spratley, S.C. Graham, J.E. Deane (2018) The mechanism of sphingolipid processing revealed by a GALC-SapA complex structure. Nature Communications, 9: 151 doi: 10.1038/s41467-017-02361-y
  27. M.R. Hunter*, E.J. Scourfield*, E. Emmott, S.C. Graham (2017) VPS18 recruits VPS41 to the human HOPS complex via a RING-RING interaction. Biochemical Journal, 474: 3615–3626 doi: 10.1042/BCJ20170588
  28. A. Albecka, D.J. Owen, L. Ivanova, J. Brun, R. Liman, L. Davies, M.F. Ahmed, S. Colaco, M. Hollinshead, S.C. Graham^ and C.M. Crump^ (2017) Dual function of the pUL7-pUL51 tegument protein complex in HSV-1 infection. Journal of Virology, 91: e02196-16 doi: 10.1128/JVI.02196-16
  29. J. Muenzner, L.M. Traub, B.T. Kelly^, S.C. Graham^ (2017) Cellular and viral peptides bind multiple sites on the N-terminal domain of clathrin. Traffic, 18: 44–57 doi: 10.1111/tra.12457
  30. B.T. Kelly, S.C. Graham, D.J. Owen (2016) Using selenomethionyl derivatives to assign sequence in low-resolution structures of the AP2 clathrin adaptor. Acta Crystallographica Section D: Biological Crystallography, 72: 336–345 doi: 10.1107/S2059798315021580
  31. E.N. Leen, F. Sorgeloos, S. Correia, Y. Chaudhry, F. Cannac, C. Pastore, Y. Xu, S.C. Graham, S.J. Matthews, I.G. Goodfellow, S. Curry (2016) A conserved interaction between a C-terminal motif in Norovirus VPg and the HEAT-1 domain of eIF4G is essential for translation initiation. PLoS Pathogens, 12: e1005379 doi: 10.1371/journal.ppat.1005379
  32. D.J. Owen, C.M. Crump, S.C. Graham (2015) Tegument Assembly and Secondary Envelopment of Alphaherpesviruses. Viruses, 7: 5084–5114 doi: 10.3390/v7092861
  33. L. Wartosch, U. Günesdogan, S.C. Graham, J.P. Luzio (2015) Recruitment of VPS33A to HOPS by VPS16 is required for lysosome fusion with endosomes and autophagosomes. Traffic, 16: 727–742 doi: 10.1111/tra.12283
  34. S. Neidel, C. Maluquer de Motes, D.S. Mansur, P. Strnadova, G.L. Smith, S.C. Graham (2015) Vaccinia Virus Protein A49 is an Unexpected Member of the B-cell Lymphoma (Bcl)-2 Protein Family. Journal of Biological Chemistry, 290: 5991–6002 doi: 10.1074/jbc.M114.624650
  35. B.T. Kelly, S.C. Graham, N. Liska, P.N. Dannhauser, S. Höning, E.J. Ungewickell, D.J. Owen (2014) AP2 controls clathrin polymerization with a membrane-activated switch. Science, 345: 459–463 doi: 10.1126/science.1254836
  36. C.H. Hill, S.C. Graham, R.J. Read, J.E. Deane (2013) Structural snapshots illustrate the catalytic cycle of β-galactocerebrosidase, the defective enzyme in Krabbe disease. Proceedings of the National Academy of Sciences of the USA, 110: 20479–20484 doi: 10.1073/pnas.1311990110
  37. Y. Hackmann, S.C. Graham^, S. Ehl, S. Höning, K. Lehmberg, M. Aricò, D.J. Owen, G.M. Griffiths^ (2013) Syntaxin binding mechanism and disease-causing mutations in Munc18-2. Proceedings of the National Academy of Sciences of the USA, 110: E4482–E4491 doi: 10.1073/pnas.1313474110
  38. S.C. Graham*^, L. Wartosch*, S.R. Gray, E.J. Scourfield, J.E. Deane, J.P. Luzio^, D.J. Owen (2013) Structural basis of Vps33A recruitment to the human HOPS complex by Vps16. Proceedings of the National Academy of Sciences of the USA, 110: 13345–13350 doi: 10.1073/pnas.1307074110
  39. M.W. Bahar, L.P. Sarin, S.C. Graham, J. Pang, D.H. Bamford, D.I. Stuart, J.M. Grimes (2013) Structure of a VP1-VP3 complex suggests how birnaviruses package the VP1 polymerase. Journal of Virology, 87: 3229–3236 doi: 10.1128/JVI.02939-12
  40. C. Maluquer de Motes, S. Cooray, K. McGourty, H. Ren, M.W. Bahar, D.I. Stuart, J.M. Grimes, S.C. Graham, G.L. Smith (2011) Inhibition of apoptosis and NF-κB activation by vaccinia protein N1 occur via distinct binding surfaces and make different contributions to virulence. PLoS Pathogens, 7: e1002430 doi: 10.1371/journal.ppat.1002430
  41. S.E. Miller*, D. Sahlender*, S.C. Graham, S Höning, M.S. Robinson, A.A. Peden, D.J. Owen (2011) The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM. Cell, 147: 1118–1131 doi: 10.1016/j.cell.2011.10.038
  42. J.E. Deane, S.C. Graham, N.N. Kim, P.E. Stein, R. McNair, M.B. Cachón-González, T.M. Cox, R.J. Read (2011) Insights into Krabbe Disease from the Structure of Galactocerebrosidase. Proceedings of the National Academy of Sciences of the USA, 108: 15169–15173 doi: 10.1073/pnas.1105639108
  43. M.W. Bahar, S.C. Graham, D.I. Stuart, J.M. Grimes (2011) Insights into the evolution of a complex virus from the crystal structure of vaccinia virus D13. Structure, 19: 1011–1020 doi: 10.1016/j.str.2011.03.023
  44. M.W. Bahar*, S.C. Graham*, R. Chen, S. Cooray, G.L. Smith, D.I. Stuart, J.M. Grimes (2011) How vaccinia virus has evolved to subvert the host immune response. Journal of Structural Biology, 175: 127–134 doi: 10.1016/j.jsb.2011.03.010
  45. S.C. Graham*, L.P. Sarin*, M.W. Bahar, R.A. Myers, D.I. Stuart, D.H. Bamford, J.M. Grimes (2011) The N-terminus of the RNA polymerase from Infectious Pancreatic Necrosis Virus is the determinant of genome attachment. PLoS Pathogens, 7: e1002085 doi: 10.1371/journal.ppat.1002085
  46. C.T. Benfield, D. Mansur, L.E. McCoy, B.J. Ferguson, M.W. Bahar, A.P. Oldring, J.M. Grimes, D. I. Stuart, S.C. Graham^, G.L. Smith^ (2011) Mapping the IκB kinase beta (IKKβ)-binding interface of B14, a vaccinia virus inhibitor of IKKβ-mediated activation of nuclear factor κB. Journal of Biological Chemistry, 286: 20727–20735 doi: 10.1074/jbc.M111.231381
  47. D. Bubeck, M.A.M. Reijns, S.C. Graham, K.R. Astell, E.Y. Jones, A.P. Jackson (2011) PCNA directs Type 2 RNase H activity on DNA replication and repair substrates. Nucleic Acids Research, 39: 3652–3366 doi: 10.1093/nar/gkq980
  48. M.A.M. Reijns*, D. Bubeck*, L.C. Gibson, S.C. Graham, G.S. Baillie, E.Y. Jones, A.P. Jackson (2011) The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease. Journal of Biological Chemistry, 286: 10530–10539 doi: 10.1074/jbc.M110.177394
  49. R. Assenberg, O. Delmas, B. Morin, S.C. Graham, X. De Lamballerie, C. Laubert, B. Coutard, J.M. Grimes, J. Neyts, R.J. Owens, B.W. Brandt, A. Gorbalenya, P. Tucker, D.I. Stuart, B. Canard, H. Bourhy (2010) Genomics and structure/function studies of Rhabdoviridae proteins involved in replication and transcription. Antiviral Research, 87: 149–161 doi: 10.1016/j.antiviral.2010.02.322
  50. R. Assenberg, O. Delmas, J. Ren, P.O. Vidalain, A. Verma, F. Larrous, S.C. Graham, F. Tangy, J.M. Grimes, H. Bourhy (2010) The Structure of the N-RNA Binding Domain of the Mokola virus Phosphoprotein. Journal of Virology, 84: 1089–1096 doi: 10.1128/JVI.01520-09
  51. D. Hatherley, S.C. Graham, K. Harlos, D.I. Stuart, A.N. Barclay (2009) Structure of signal regulatory protein α: a link to antigen receptor evolution. Journal of Biological Chemistry, 284: 26613–26619 doi: 10.1074/jbc.M109.017566
  52. T.A. Bowden, M. Crispin, S.C. Graham, D.J. Harvey, J.M. Grimes, E.Y. Jones, D.I. Stuart (2009) Unusual Molecular Architecture of the Machupo Virus Attachment Glycoprotein. Journal of Virology, 83: 8259–8265 doi: 10.1128/JVI.00761-09
  53. B.L. Walter, A.E. Armitage, S.C. Graham, T. de Oliveira, P. Skinhøj, E.Y. Jones, D.I. Stuart, A.J. McMichael, B. Chesebro, A.K. Iversen (2009) Functional characteristics of HIV-1 subtype C compatible with increased heterosexual transmissibility. AIDS, 23: 1047–1057 doi: 10.1097/QAD.0b013e32832a1806
  54. S.C. Graham, R. Assenberg*, O. Delmas*, A. Verma, A. Gholami, C. Talbi, R.J. Owens, D.I. Stuart, J.M. Grimes, H. Bourhy (2008) Rhabdovirus matrix protein structures reveal a novel mode of self-association. PLoS Pathogens, 4: e1000251 doi: 10.1371/journal.ppat.1000251
  55. S.C. Graham*, M.W. Bahar*, S. Cooray*, R.A.J. Chen, D.M. Whalen, N.G.A. Abrescia, D. Alderton, R.J. Owens, D.I. Stuart, G.L. Smith, J.M. Grimes (2008) Vaccinia virus proteins A52 and B14 share a Bcl-2−like fold but have evolved to inhibit NF-κB rather than apoptosis. PLoS Pathogens, 4: e1000128 doi: 10.1371/journal.ppat.1000128
  56. D. Hatherley*, S.C. Graham*, K. Harlos, J. Turner, D.I. Stuart, A.N. Barclay (2008) Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47. Molecular Cell, 31: 266–277 doi: 10.1016/j.molcel.2008.05.026
  57. J.E. Deane, S.C. Graham, E.P. Mitchell, D. Flot, S. Johnson, S.M. Lea (2008) Crystal structure of Spa40, the specificity switch for the Shigella flexneri Type III Secretion System. Molecular Microbiology, 69: 267–276 doi: 10.1111/j.1365-2958.2008.06293.x
  58. R. Assenberg, O. Delmas, S.C. Graham, A. Verma, N. Berrow, D.I. Stuart, R.J. Owens, H. Bourhy, J.M. Grimes (2008) Expression, purification and crystallization of a lyssavirus matrix (M) protein. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 64: 258–262 doi: 10.1107/S1744309108004557
  59. S.C. Graham, J.M. Guss (2008) Complexes of mutants of Escherichia coli aminopeptidase P and the tripeptide substrate ValProLeu. Archives of Biochemistry and Biophysics, 469: 200–208 doi: 10.1016/j.abb.2007.10.009
  60. T.S. Walter, E.J. Mancini, J. Kadlec, S.C. Graham, R. Assenberg, J. Ren, S. Sainsbury, R.J. Owens, D.I. Stuart, J.M. Grimes, K. Harlos (2008) Semi-Automated Microseeding of Nanolitre Crystallization Experiments. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 64: 14–18 doi: 10.1107/S1744309107057260
  61. S.C. Graham, M.W. Bahar, N.G.A. Abrescia, G.L. Smith, D.I. Stuart, J.M. Grimes (2007) Structure of CrmE, a Virus-encoded Tumour Necrosis Factor Receptor. Journal of Molecular Biology, 372: 660–671 doi: 10.1016/j.jmb.2007.06.082
  62. M. Lee, C.W. Chan, S.C. Graham, R.I. Christopherson, J.M. Guss, M.J. Maher (2007) Structures of Ligand-free and Inhibitor Complexes of Dihydroorotase from Escherichia coli: Implications for Loop Movement in Inhibitor Design. Journal of Molecular Biology, 370: 812–825 doi: 10.1016/j.jmb.2007.05.019
  63. C.M. Jeffries, S.C. Graham, P.H. Stokes, C.A. Collyer, J.M. Guss, J.M. Matthews (2006) Stabilization of a binary protein complex by intein-mediated circularization. Protein Science, 15: 2612–2618 doi: 10.1110/ps.062377006
  64. S.C. Graham, P.E. Lilley, M. Lee, P.M. Schaeffer, A.V. Kralicek, N.E. Dixon, J.M. Guss (2006) Kinetic and crystallographic analysis of mutant Escherichia coli aminopeptidase P: Insights into substrate recognition and the mechanism of catalysis. Biochemistry, 45: 964–975 doi: 10.1021/bi0518904
  65. S.C. Graham, C.S. Bond, H.C. Freeman, J.M. Guss (2005) Structural and functional implications of metal ion selection in aminopeptidase P, a metalloprotease with a dinuclear metal centre. Biochemistry, 44: 13820–13836 doi: 10.1021/bi0512849
  66. S.C. Graham, M.J. Maher, W.H. Simmons, H.C. Freeman, J.M. Guss (2004) Structure of Escherichia coli aminopeptidase P in complex with the inhibitor apstatin. Acta Crystallographica Section D: Biological Crystallography, 60: 1770–1779 doi: 10.1107/S0907444904018724
  67. D.B. Langley, D.W.S. Harty, S.C. Graham, J.M. Guss, N. Hunter, C. Collyer (2004) Crystallization of GcnA, an N-acetyl-β-D-glucosaminidase, from Streptococcus gordonii. Acta Crystallographica Section D: Biological Crystallography, 60: 1910–1911 doi: 10.1107/S0907444904019572
  68. J.E. Deane, M.J. Maher, D.B. Langley, S.C. Graham, J.E. Visvader, J.M. Guss, J.M. Matthews (2003) Crystallization of FLINC4, an intra-molecular LMO4:ldb1 complex. Acta Crystallographica Section D: Biological Crystallography, 59: 1484–1486 doi: 10.1107/S0907444903011843
  69. S.C. Graham, M. Lee, H.C. Freeman, J.M. Guss (2003) An orthorhombic form of Escherichia coli aminopeptidase P at 2.4 Å resolution. Acta Crystallographica Section D: Biological Crystallography, 59: 897–902 doi: 10.1107/S0907444903005870
  70. W.M. Shui, R.K. Wong, S.C. Graham, L. Lee, W.B. Church (2003) Integrating, Managing and Analyzing Protein Structures with XML Databases. Proceedings of the 8th International Conference on Database Systems for Advanced Applications, 319–326 doi: 10.1109/DASFAA.2003.1192397
  71. W.M. Shui, R.K. Wong, S.C. Graham, L. Lee, W.B. Church (2003) A new approach to protein structure and function analysis using semi-structured databases. Proceedings of the First Asia Pacific Bioinformatics Conference, 61–69 http://crpit.com/confpapers/CRPITV19Shui.pdf
  72. R.K. Wong, F. Lam, S. Graham, W. Shui (2000) An XML Repository for Molecular Sequence Data. Proceedings of the First IEEE International Symposium on Bio-Informatics and Biomedical Engineering, 35–42 doi: 10.1109/BIBE.2000.889587