Stephen Graham's Lab Home

News:

01/10/23 - We're hiring! Looking for a postdoc to work on an exciting project to enhance pandemic preparedness by understanding how viral enzymes can evolve antiviral resistance. More details and apply here!
29/9/23 - Congratulations to Henry on passing his PhD viva!!
18/7/23 - Our collaborative paper with the Lulla lab on human astrovirus neuronal infection has been published in PLoS Biology.
24/4/23 - We're hiring! We have a fully-funded PhD studentship available to study how protein phosphorylation regulates virus cell-to-cell spread. More details here.
21/4/23 - Stephen has published a preprint with Nerea Irigoyen's lab on Zika virus neurovirulence.
31/3/23 - Stephen and Janet Deane have run a practical course on protein chemistry in Brazil.
9/1/23 - Welcome to Giulia, who will be visiting from the Viral Glycoproteins lab @ The Pirbright Institute to sharpen her protein chemistry skills!
8/12/22 - Natalia's paper on Oropouche virus glycoprotein secretion has been published in Journal of Virology.
26/11/22 - Another month, another collaborative ppaer on receptor protein tyrosine phosphatases published in JBC!
21/10/22 - Stephen's collaborative paper on PTPRK substrate recruitment has been published in eLife.
14/10/22 - Tomasz's paper on cellular lipid transport hijacking by HSV-1 has been published in JBC.
12/10/22 - Congratulations to Kamal on passing his PhD viva!
3/10/22 - Welcome to Holly, who has joined us for a 3 month rotation, and Dan who's joining us for a PhD!
1/10/22 - Stephen's been promoted! He's now the Professor of Virus:Host Interactions @ Cambridge Uni.
16/9/22 - Stephen has published a preprint on the molecular link between lipid metabolism and demyelination with the Janet Deane's lab in CIMR.
8/9/22 - Stephen has published a preprint on astrovirus attenuation and neuroinfection with his friends in the Lulla lab.
25/8/22 - We've posted an updated preprint of Natalia's Oropouche virus glycoprotein secretion story to BioRχiv.
22/8/22 - Diamond Light Source has published an article on Kamal's cryoSXT paper.
13/7/22 - New lab print: quick and simple 50 mL Falcon tube covers. See 3D Prints page for details.
8/7/22 - Kamal's paper on cryo soft X-ray tomography imaging of HSV-1 infection has been published in PLoS Pathogens!
25/6/22 - Stephen has published a a preprint the basis of receptor tyrosine phosphatase homophilic adhesion.
11/6/22 - Congratulations Dan for winning the Part II (undergraduate) prize for best virology project!
2/6/22 - Stephen and Tomasz have published a preprint on herpesvirus regulation of host-cell lipid metabolism.
31/5/22 - Congratulations to Ben for passing his PhD viva!!
20/5/22 - Kamal's contact paper is now out in print!
30/4/22 - Congratulation to Ben for handing in his PhD thesis!
28/4/22 - Stephen has published a preprint on recruitment of Afadin to PTPRK.
22/4/22 - Kamal's work on cryo soft X-ray tomography imaging of HSV-1 infection got a write-up on the Department of Pathology website.
23/2/22 - Congratulations to Tomasz (or should I say Dr Benedyk) on passing his PhD viva!
13/1/22 - Our paper on vaccinia virus E2 and the prediction of novel virus structures by AlphaFold2 has been published in the Journal of General Virology.
9/12/21 - Stephen's paper with Chris Hill and friends on EMCV 2A has been published in Nature Communications.
5/12/21 - Kamal has published a preprint describing his semi-automated cryoSXT segmentation tool.
17/11/21 - Stephen's paper with Janet Deane's lab has now been published.
11/11/21 - It's with great sadness that we say goodbye to Susanna - we wish her all the best for her retirement!
9/11/21 - Stephen's collaborative paper on ribosomal frameshifting in Theilovirus has been published in Nucleic Acids Research.
22/10/21 - Join us! We have a fully-funded PhD studentship available. Details here.
15/10/21 - Stephen and Tomasz's paper on pUL21 has been highlighted on the EMBL website.
15/10/21 - Stephen has published a preprint describing the structure of vaccinia virus protein E2.
12/10/21 - Stephen and Kamal have published a preprint on BioRχiv about cryo-soft-X-ray tomography imaging of HSV-1 infected cells.
4/10/21 - Welcome to Dan, who will be doing his 10-week undergraduate project in the lab.
23/9/21 - Congratulatons to Alison on passing her MPhil viva!
27/8/21 - Stephen has published a preprint with Janet Deane's lab on the structure of a lipid transfer protein.
16/8/21 - Stephen and Tomasz's paper has been published in PLoS Pathogens!
6/7/21 - Welcome to Zara, our summer intern!
14/4/21 - Stephen, Tomasz and friends have published a preprint that identifies pUL21 as a phosphatase adaptor required for efficient HSV-1 replication.
24/3/21 - Stephen has published a paper on the use of error-prone PCR to map virus:host interactions with friends from The Pribright Institute.
8/2/21 - Welcome to Monique, who has joined our lab to develop protein-based tools to detect and prevent Oropouche virus infection.
15/1/21 - The SARS-CoV-2 receptor paper has been featured in the Cambridge Independent.
8/1/21 - Stephen's paper on SARS-CoV-2 receptor usage has been highlighted on the University of Cambridge webstite.
22/12/20 - Stephen has published a paper on the ability of SARS-CoV-2 to use different mammalian ACE2 receptors in PLoS Biology.
8/10/20 - Welcome to Alison, a new MPhil in the lab who'll be investigating structural aspects of HCMV infection.
5/10/20 - Stephen, Henry and Julia have published a paper on HSV modulation of infected cells in Cell reports.
11/9/20 - Goodbye and good luck to Han, who is leaving the lab to take up an exciting position with a major pharma company in Shanghai.
12/8/20 - Stephen has published a brace of preprints with Chris Hill and friends on how cardioviruses make ribosomes swap reading frames.
1/7/20 - Stephen, Ben and Edward have published a non-native protein structure.
19/6/20 - Stephen has published a preprint on SARS-CoV-2 spike receptor usage across species with friends from The Pirbright Institute.
11/6/20 - eLife has published a plain-text summary of Ben and Stephen's recent paper on HSV-1 assembly.
31/5/20 - Stephen and Natalia have published a preprint on Oropouche virus assembly.
11/5/20 - Despite the lab being closed, the science rolls on! We're happy to share our latest work on HSV-1 pUL7 and pUL51, published at eLife.
20/3/20 - The lab has temporarily closed down due to the ongoing COVID-19 pandemic. We're all working from home so that we can stay safe and help prevent community transmission of the virus.
13/12/19 - Lab Christmas party! Have a look at the photos page for some happy snaps.
29/10/19 - Welcome to Han, a new postoc in the lab who will be studying how herpesviruses modulate host-cell lipid transport.
16/9/19 - Welcome back to Henry, a Wellcome Trust Infection, Immunity and Inflammation student who'll be staying on with us for his PhD.
8/8/19 - Stephen and Julia have published a pre-print showing how HSV-1 specifically degrades a cellular trafficking factor to re-model the plasma membrane of infected cells!
3/8/19 - Our collaborative paper on CD1-saposin interactions has now been published on Wellcome Open Research.
12/7/19 - Tomasz and Stephen have published a preprint on CD1-saposin interactions with our friends in Janet Deane's lab.
5/6/19 - Stephen has published a letter to the editor in PNAS.
11/5/19 - We're hiring! We're looking for a viologist (or virology-curious cell biologist) to join the lab. Drop Stephen an email for more details and apply here.
2/5/19 - Welcome to Natalia, who is joining us from Luis da Silva's lab in Brazil for 8 months to study Oropouche virus assembly.
18/3/19 - We're hiring! We're looking for a protein biochemist or cell biologist to join the team looking at how viruses change the composition of membranes during infection. See here for more info and apply via the University jobs portal.
17/3/19 - Thanks to everyone for making our "Grow your own crystal" stand at the Cambridge Science Festival a success! Check out the photos here.
28/2/19 - Congratulations to Chen, whose paper has been accepted by JBC! Chen managed to time things very well, as today was also the day she moved to Geoff Smith's lab to continue working on vaccinia virus immune evasion.
15/2/19 - Stephen has been profiled on the Wellcome Trust website as part of their series of "researcher profiles".
14/2/19 - Stephen has published a paper in Science. Read the associated commentary or even the Daily Mail article!
7/1/19 - Welcome to Henry, a Wellcome Trust Infection, Immunity and Inflammation student doing a 10-week rotation in the lab.
4/12/18 - Congratuations to Ben, whose first paper has been published in J. Gen. Virol..
5/11/18 - Chen and Stephen's new paper on vaccinia virus immunomodulation has been posted as a preprint on BioRχiv.
1/10/18 - Welcome to Kamal, a new PhD student who will be working with us and Colin Crump in Cambridge, and Maria Harkiolaki at Diamond, on Cryo X-ray tomography.
19/9/18 - Stephen has published a paper on emerging morbilliviruses with Dalan Bailey from Pirbright.
12/9/18 - We had a film-crew in the lab today! Have a look at some behind-the-scenes shots here.
30/8/18 - Welcome back to Ben, who survived a rotation in the lab and has decided to come back for more (in the form of a PhD).
20/7/18 - Welcome to Kaveesha, a new postdoc in the lab.
17/5/18 - Morag, Tomasz and Stephen's paper on the human VSP33A and VPS33B interactomes published in JMB.
18/4/18 - Our paper on GALC has been selected for the Nature Communications front page!
16/4/18 - Welcome to Ben, a new Wellcome Trust Infection, Immunity and Inflammation student doing a 10-week rotation in the lab.
17/3/18 - The lab hosted a "Grow your own crystal" stand at the Cambridge Science Festival. It was great fun - check out the photos here.
15/3/18 - Stephen's paper with Trevor Sweeney's lab has been published in Nucleic Acids Research.
11/3/18 - Tomasz invited the lab to formal hall at Sidney Sussex College - see the photos here.
8/2/18 - Stephen's work with Trevor Sweeney's lab on IFIT anti-viral proteins has been submitted to BioRχiv
12/1/18 - We're looking for a PhD candidate to join the lab in October on a collaborative project with Diamond Light Source. Details here.
12/1/18 - We're looking for a postdoc to work on membrane remodelling by viruses. Details here.
11/1/18 - Stephen's paper with Janet Deane's lab on the GALC-SapA structure has been published in Nature Communications.
10/1/18 - Welcome to Tomasz, our new PhD student.
20/12/17 - Goodbye to Morag, who's leaving the lab for a job in industry...and congratulations for gettting her paper submitted to BioRχiv before leaving!
13/12/17 - Check out some photos of the lab Christmas party. Happy holidays!
11/12/17 - Goodbye to Julia, who is leaving the lab after 4½ fun years as a PhD student then postdoc.
30/11/17 - Lab funding news: Stephen has been awarded a 3-year extension of his Sir Henry Dale Fellowship. We'll be looking for a new postdoc to join the lab in the new year, so stay tuned!
6/11/17 - Congratulations to Danielle for passing her PhD viva! See some photos here.
9/10/17 - Welcome to Cameron, a Wellcome Trust Infection, Immunity and Inflammation student doing a 10-week rotation in the lab.
2/10/17 - Welcome to Eve, and undergraduate student who's doing her third year project in the lab.
21/9/17 - Morag, Edward and Stephen's paper on HOPS assembly has been published, hooray!
25/8/17 - Congratulations to Julia for passing her PhD viva! See a photo here.
27/7/17 - Stephen, Morag and Edward have published a new online preprint on BioRχiv.
3/7/17 - Congratulations to Chen, who has just been made a Postdoctoral Affiliate of Newnham College.
26/6/17 - We have a fully-funded studentships for a PhD candidate to join the lab from January 2018 - see here for more details.
23/6/17 - Congratulations to Alice, who won the 2017 Department of Pathology prize for best Virology undergraduate project report.
11/6/17 - We're hiring! We're looking for a postdoc to drive our work on virus modulation of focal adhesions. See the ad here.
18/4/17 - Welcome to Maria, a Wellcome Trust Infection, Immunity and Inflammation student doing a 10-week rotation in the lab.
31/3/17 - We are sad to say goodbye to Lydumila, who is moving back to Germany after a fun and productive 12 months in the lab.
18/3/17 - Back by popular demand, we hosted a grow your own crystals stand at the Cambridge Science Festival.
28/2/17 - Stephen has published a preprint on bioRxiv describing a novel lipid hydrolase complex.
23/12/16 - Julia's Traffic paper has just appeared on the front cover of Traffic!
16/11/16 - Danielle, Lyudmila, Susanna and Stephen have published a paper in J. Virol. on the HSV pUL7/pUL51 complex.
4/11/16 - Julia and Stephen have published a paper in Traffic on the binding of cellular and viral proteins to clathrin.
3/10/16 - Welcome to Alice, an undergraduate student who's doing her third year project in the lab.
9/9/16 - Last week we stepped away from the bench for a lab retreat - check out the photos here.
15/7/16 - New lab publication (of sorts)...Stephen's had a letter to the editor published in The Economist.
24/6/16 - The lab co-hosted a Pathology Department social. Check out the photos here.
1/4/16 - Welcome to Lyudmila, a new postdoc in the lab who will investigate HSV replication and spread.
1/3/16 - Stephen has published a paper on the methods used in their recent paper on AP2 activation.
17/12/15 - We're hiring! We're looking for a postdoc to work with our lab and Colin Crump's lab on herpesvirus spread. See here for details.
12/10/15 - Welcome to Chen, a new postdoc in the lab who will be working in both our lab and Geoffrey Smith's lab on poxvirus immune evasion.
12/10/15 - Welcome to Guido, a Wellcome Trust Infection, Immunity and Inflammation student doing a 10-week rotation in the lab.
18/9/15 - After almost 3 years in the lab Edward has moved on to pursue a PhD in London. We wish him all the best in his studies.
18/9/15 - Danielle and Stephen have published review of HSV egress...Danielle's first paper - congratulations!
16/9/15 - It was a long day, but we've successfully moved into a new lab space. Many thanks to everyone in the lab for pitching in and making the move go smoothly!
10/8/15 - Stephen has entered a brave new world of online publishing; he's co-author on a preprint posted to BioRχiv.
30/7/15 - Welcome to Morag, our new postdoc who's moved to Cambridge from New Zealand.
20/4/15 - Congratulations to Julia - she won the prize for best poster at the Pathology Department research symposium.
25/3/15 - We're hiring! We're looking for a postdoc to help characterise molecular determinants of lysosomal membrane fusion. See here for details.
19/3/15 - Stephen has just published a paper in Traffic on how VPS33A recruitment to the human HOPS complex by VPS16 is required for fusion of late endosomes and autophagosomes with lysosomes.
20/2/15 - Stephen has written a short piece on poxvirus immune modulation for the Discussion section of the University website.
21/1/15 - Stephen and Sarah have published a paper in JBC on the structure and evolution of the vaccinia virus immunomodulatory protein A49.
10/1/15 - There's a postdoc job going in the lab to work on modulation of the host immune system by vaccinia virus. See here for details.
7/10/14 - Welcome to Yee Tat, a Part II (undergraduate) medical student spending 12 weeks in the lab.
22/8/14 - The paper on clathrin recruitment by AP2 has been summarised in Nature Reviews - Molecular Cell Biology.
25/7/14 - Stephen has published a paper in Science.
15/3/14 - The lab hosted a "Grow your own crystals" event as part of the 2014 Cambridge Science Festival (photos).
7/12/13 - Stephen and Edward's paper in PNAS has been recommended by Faculty of 1000.
3/12/13 - Stephen has published another couple of papers in PNAS, see here for details.
2/10/13 - Welcome to Danielle and welcome back to Julia, who have both joined the lab for PhDs.
31/7/13 - Stephen and Edward have published a paper in PNAS.
8/4/13 - Welcome to Julia, a Wellcome Trust Infection and Immunity student who will be doing a 10 week rotation in the lab.
29/1/13 - There is a fully funded PhD studentship available in the lab. See here for details.
1/10/12 - The lab is now up and running in the Virology Division of the Department of Pathology, University of Cambridge.

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Upcoming Talks:

IPNV VP1 We are interested in the molecular mechanisms used by viruses to invade host cells, establish an infection and ensure that progeny virus particles are released into the environment, all while evading the host's immune defences. We are especially interested in how large double-stranded DNA viruses like herpes simplex virus and vaccinia virus (the smallpox vaccine) subvert the membrane trafficking machinery and innate immune defences of human cells.

To study these problems we use a host of structural, biochemical, biophysical and cell-based techniques including protein X-ray crystallography, mass spectrometry, fluorescence microscopy, infection studies, multi-angle light scattering, differential scanning fluorimetry, isothermal titration calorimetry, surface plasmon resonance and fluorescence anisotropy.

UL51 UL7 IF By using viruses as tools to better understand the inner workings of cells, we aim to make insights into virus biology that will underpin the next generation of vaccines and anti-viral drugs.

Most importantly, we work as a team to do great science. Ours is a collaborative lab environment that aims to support the personal and professional development of every member, regardless of their background, gender identity, colour, accent or who they love.

Atomic Virology Lab

University of Cambridge

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